Table 3.

Liver histopathological scoring of healthy and NASH rats receiving either CDDP or vehicle.

Disease	Drug	Total	Lipid accumulation	Necrosis	Apoptosis	Inflammation	Fibrosis	Biliary hyperplasia
Control	Naïve	0	0	0	0	0	0	0
	CDDP	0	0.17 ± 0.41	0	0	0	0	0
NASH	Naïve	2.33 ± 0.52	3.50 ± 0.55	0.83 ± 0.41	0.33 ± 0.52	1.67 ± 0.52	0.33 ± 0.52	1.50 ± 1.05
	CDDP	1.80 ± 0.45	2.80 ± 0.45	0.40 ± 0.55	0.80 ± 0.45	1.60 ± 0.55	0	1.40 ± 0.55
Two-way ANOVA	Diet	∗∗∗∗	∗∗∗∗	∗∗∗	∗∗∗	∗∗∗∗	ns	∗∗∗∗
	Drug	ns	ns	ns	ns	ns	ns	ns

Mean scores represent n = 6 rats/group with the total being the average of the sum of all scores.

Means were compared by two-way analysis of variance where P < 0.05 (∗), <0.01 (∗∗), <0.001 (∗∗∗), <0.0001 (∗∗∗∗).