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. 2021 Jun 25;11(12):4008–4019. doi: 10.1016/j.apsb.2021.04.003

Figure 1.

Figure 1

JOSD2 is a new regulator of YAP/TAZ in CCA. YAP (A) or TAZ (B) silencing significantly impedes HuCCT-1, RBE and CCLP-1 cell proliferation as determined by SRB assay. These results represent the mean ± SD of three independent experiments; ∗∗P < 0.01, ∗∗∗P < 0.001. Knock-down of YAP (C) or TAZ (D) dramatically suppresses CCA colony formation as displayed by SRB assay. (E) The scheme for identification of JOSD2 as a candidate DUB of YAP in CCA. (F) JOSD2 expression level is significantly up-regulated in CCA tumor tissues; ∗∗∗P < 0.001.