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. 2021 Sep 8;11(12):3756–3767. doi: 10.1016/j.apsb.2021.09.002

Figure 2.

Figure 2

Effect of VC on metabolic phenotype and mitochondrial morphology. (A) Representative parameters of metabolic function are depicted for mice exposed to HFD ± VC32. (B) Representative EM photomicrographs depict elongated organelles in the HFD group and enlarged mitochondria (width, length >1 mm) in the HFD + VC group. Arrows denote mitochondria, LD denote lipid droplet, and N denotes nucleus. (C) Total mitochondrial area (μm2) and mitochondrial length/width ratio are shown. (D) The ratio of hepatic mitochondrial to nuclear DNA (mtDNA:nuDNA) is shown as fold of control compared to LFD control animals. (E) Distribution of the size of 70 mitochondria/group are shown. aP < 0.05 compared to LFD or HFD control. Samples size per group n = 8–10.