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. 2021 Dec 22;13:778527. doi: 10.3389/fnagi.2021.778527

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Copyright © 2021 Yang, Wang, Deng, Li, Zhao and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fibroblast growth factor 21 (FGF21) treatment prevented the motor deficits of mice with PD. (A) Schematic of the experimental procedure. (B) Time to descend pole. (C) Rotarod test. (D) Track of mice in open field test. (E) Distance traveled in the center for 5 min. Data are mean ± s.e.m.; n = 6–8 for each group. One-way ANOVA was conducted for statistical analysis followed by an LSD multiple comparison test. **P < 0.01 vs. control (CON) group; ^#P < 0.05, ^###P < 0.001 vs. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-injected mice.