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. 2021 Dec 22;13:778527. doi: 10.3389/fnagi.2021.778527

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Copyright © 2021 Yang, Wang, Deng, Li, Zhao and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FGF21 treatment prevented the cognitive deficits of mice with PD. (A) Escape latency during 4 training days. (B) Representative swim paths. (C) Distance in the target quadrant. (D) Number of crossing the place of the platform. (E) Spontaneous alteration in the Y-maze. Data are mean ± s.e.m.; n = 6–8 for each group. A one-way ANOVA was used for statistical analysis followed by an LSD multiple comparison test. *P < 0.05, ***P < 0.001 vs. CON group; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. MPTP-injected mice.