Figure 5.

PEG-ASNase-induced liver injury is exacerbated in obese and 72-week-old mice. Obese and aged (72-week-old) mice receiving PEG-ASNase (A) lost over 10% of their body weight, (B) had elevated hepatic triglyceride (TG) concentrations (representative pictures of livers from different treatment groups are shown in the upper panel), and (C) higher plasma direct bilirubin concentrations compared to obese or age-matched control mice, respectively. (D) Aged mice had lower PPARα and HADHB protein levels compared to 8-week-old mice, which were slightly elevated after PEG-ASNase treatment. Data in (A)–(C) from n ≥ 3 mice per group.