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MiR-124-3p controls focal adhesion plaques in human NSCLC A549 and osteosarcoma 143B cells. Confocal images showed that there were much sparser and less vinculin-containing focal adhesion plaques (green, white arrowheads) distributed along the distorted or compressed actin filaments (red) or enriched at the plasma membrane regions in cells treated with miR-124-3p, as compared with control LSA or vehicle treatments. Nuclei are labeled in blue. Scale bar, 10 μm.
