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Expression of Loxl2 regulated genes from human age-related disorders. (A–E) RT-qPCR for 5–6 replicates of 10 whole da(GS)-GAL4 × UAS-Loxl2 RNAi flies +/−RU induction (starting on day 5) from four time points in the Drosophila lifespan. CadN2 was significantly upregulated when Loxl2 is repressed at week three and seven; one outlier was removed from each sample before analysis. Unpaired t-test *P ≤ 0.05, **P ≤ 0.01, *** P ≤ 0.001, **** P ≤ 0.0001, ns, not significant.
