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. 2021 Oct 21;12(1):jkab364. doi: 10.1093/g3journal/jkab364

Figure 1.

Figure 1

Increase in mutation rates in fog-2(q71); msh-2(RNAi) knockdown MA lines compared with wild type. (A) Base substitution rates are significantly lower than small indel rates in the obligately outcrossing msh-2 knockdown lines. Rates are calculated as per site per generation. (B) Mutation rate increase in obligately outcrossing msh-2 knockdown MA lines compared with wildtype MA lines is significantly greater for small indels compared with SNPs. For brevity, fog-2; msh-2(RNAi) in the figures refers to fog-2(q71); msh-2(RNAi) MA lines. (C) The indels/substitution ratio is significantly higher in the obligately outcrossing msh-2 knockdown MA lines compared with wildtype MA lines. (D) Sequence complexity in the vicinity of indel mutations is significantly lower than that for SNPs or randomly chosen genomic sites. Sequence context in the vicinity of SNPs is significantly lower than that for random sites. Thick horizontal black lines and red lines indicate the sample median and mean, respectively.