Table 3.
Unadjusted and Adjusteda Hazard Ratios/Incidence Rate Ratios for Outcomes, Comparing Mesh Surgery with No Surgery, in 162,578 Women with Stress Urinary Incontinence and 82,061 Women with Pelvic Organ Prolapse
| Outcome | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ratios are for Mesh Surgery, Reference Group of No Mesh Surgery | Depression, Anxiety and Self-Harm | Sexual Dysfunction | Antibiotic Prescriptions | Opioid Prescriptions | ||||||||
| Number of Observations | Unadjusted HR (95% CI) | Adjusted a HR (95% CI) | Number of Observations | Unadjusted HR (95% CI) | Adjusted a HR (95% CI) | Number of Observations | Unadjusted IRR (95% CI) | Adjusted a IRR (95% CI) | Number of Observations | Unadjusted IRR (95% CI) | Adjusted a IRR (95% CI) | |
| Stress urinary incontinence | ||||||||||||
| All women | 167,761 | 1.60 (1.54,1.66) | 0.78 (0.75,0.81) | 167,761 | 1.88 (1.55,2.29) | 1.55 (1.27,1.90) | 167,761 | 1.15 (1.12,1.18) | 1.15 (1.13,1.18) | 167,761 | 1.20 (1.17,1.23) | 0.93 (0.90,0.96) |
| No previous history of the outcome | 105,036 | 2.18 (1.97,2.42) | 2.43 (2.19,2.70) | 162,855 | 1.93 (1.55,2.41) | 1.88 (1.50,2.36) | 16,785 | 1.37 (1.21,1.55) | 1.47 (1.30,1.66) | 67,896 | 1.29 (1.16,1.44) | 1.40 (1.26,1.56) |
| Previous history of the outcome | 62,725 | 0.70 (0.67,0.73) | 0.70 (0.67,0.73) | 4906 | 0.74 (0.48,1.15) | 0.86 (0.55,1.35) | 150,976 | 1.14 (1.11,1.17) | 1.17 (1.14,1.20) | 99,865 | 1.15 (1.12,1.18) | 1.02 (0.99,1.05) |
| Pelvic organ prolapse | ||||||||||||
| All women | 83,246 | 1.28 (1.17,1.39) | 0.77 (0.70,0.84) | 83,246 | 1.33 (0.85,2.07) | 1.19 (0.76,1.87) | 83,246 | 1.13 (1.08,1.19) | 1.09 (1.04,1.14) | 83,246 | 1.03 (0.98,1.08) | 0.79 (0.74,0.84) |
| No previous history of the outcome | 59,416 | 1.39 (1.12,1.71) | 1.47 (1.19,1.81) | 81,255 | 1.52 (0.95,2.44) | 1.64 (1.02,2.63) | 34,757 | 1.27 (1.05,1.55) | 1.23 (1.01,1.49) | |||
| Previous history of the outcome | 23,830 | 0.70 (0.64,0.77) | 0.72 (0.65,0.79) | 1991 | 0.34 (0.08,1.36) | 0.32 (0.08,1.31) | 48,489 | 1.01 (0.96,1.05) | 0.91 (0.86,0.96) | |||
Notes: aRows for all women were adjusted for age (5 year groups), body mass index (<18.5, 18.5–24.9, 25–29.9, ≥30 kg/m2), deprivation quintiles, ethnicity (“white”, “Asian”, “black”, “other”/“mixed”, missing), Strategic Health Authority region, history of the outcome. Rows stratified by previous history of the outcome are adjusted for all the above variables except for previous history of the outcome.