Table 4.
Numbers Needed to Treat/Harma and Estimated 95% Confidence at 5 and 10 Years Follow-Up, for Each Outcome, for 162,578 Women with Stress Urinary Incontinence and 82,061 Women with Pelvic Organ Prolapse and Stratified by a Previous History of the Outcomeb
| Depression, Anxiety and Self-Harm | Sexual Dysfunction | Antibiotic Prescriptions | Opioid Prescriptions | |||||
|---|---|---|---|---|---|---|---|---|
| NNT 5 Years a | NNT 10 Years a | NNT 5 Years a | NNT 10 Years a | NNT 5 Years a | NNT 10 Years a | NNT 5 Years a | NNT 10 Years a | |
| Stress urinary incontinence | ||||||||
| All women b | 23.1(22.8,23.3) | 22.9 (22.7,23.1) | −206.9 (−271.4,-142.4) | −143.1 (−186.8,-99.4) | −21.3 (−21.4,-21.1) | −42.9 (−43.3,-42.6) | −276.0 (−376.9,-175.1) | −292.4 (−399.1,-185.6) |
| No previous history of the outcome b | −10.6 (−10.7,-10.6) | −8.2 (−8.3,-8.2) | −159.3 (−199.8,-118.8) | −110.2 (−137.9,-82.5) | ||||
| Previous history of the outcome b | 18.0 (17.6,18.3) | 19.2 (18.8,19.6) | c | c | ||||
| Pelvic organ prolapse | ||||||||
| All women b | 28.9 (28.4,29.3) | 27.1 (26.7,27.5) | −726.1 (−901.2,-550.9) | −544.2 (−674.0,-414.4) | −22.4 (−22.9,-22.0) | −41.3 (−42.0,-40.5) | −42.8 (−49.0,-36.6) | −44.6 (−51.0,-38.2) |
| No previous history of the outcome b | −45.1 (−46.2,-43.9) | −32.6 (−33.5,-31.8) | −271.5 (−328.3,-214.8) | −205.7 (−248.4,-163.0) | ||||
| Previous history of the outcome b | 15.7 (15.4,16.0) | 15.7 (15.4,16.1) | c | c | ||||
Notes: aPositive numbers should be interpreted as the number needed to treat: for example, at 5 years, for every 18.0 (95% CI 17.6 to 18.3) women with a previous history of depression, anxiety and self-harm who undergo SUI mesh surgery, there is 1 fewer diagnosis of depression, anxiety and self-harm. Negative numbers should be interpreted as a number needed to harm: for example, at 5 years, for every 10.6 women (95% CI 10.6 to 10.7) with no previous history of depression, anxiety and self-harm who undergo SUI mesh surgery, there is 1 extra episode of these outcomes. bEstimated from a Cox proportional hazards model, so time to first diagnosis of depression, anxiety or self-harm, or time to first prescription of antibiotics, adjusted for age (5 year groups), body mass index (<18.5, 18.5–24.9, 25–29.9, ≥30 kg/m2), deprivation quintiles, ethnicity (“white”, “Asian”, “black”, “other”/“mixed”, missing), Strategic Health Authority region, history of the outcome. Rows stratified by previous history of the outcome are adjusted for all the above variables except for previous history of the outcome. Hazard ratios and 95% confidence intervals for depression, anxiety and self-harm and sexual dysfunction are shown in Table 3, and in eTable 2 for antibiotic and opioid prescriptions. cDue to very small numbers in women aged ≥80 years with mesh surgery (<5 women), confidence intervals could not be properly estimated.