Fig. 6.

Indirect effects of empagliflozin on triglyceride (TG) synthesis. Empagliflozin enhances glycosuria by inhibiting glucose reabsorption. In obese adults after empagliflozin treatment, triglyceride synthesis following oral administration of [U–¹³C₃]glycerol was suppressed in the subjects with low VAT while the synthesis tended to increase in those with high VAT. Since the subjects with high VAT lost body weight, the increased triglyceride synthesis was presumably associated with visceral fat lipolysis, releasing glycerol and fatty acids, to compensate for glycosuria caused by empagliflozin. Abbreviations: TCA, tricarboxylic acid cycle; VAT, visceral adipose tissue; open circle = ¹²C; black circle = ¹³C; blue circle = ¹³C after metabolism through the TCA cycle. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)