Skip to main content
. Author manuscript; available in PMC: 2022 Jan 5.
Published in final edited form as: Cancer Res. 2020 Nov 6;81(2):332–343. doi: 10.1158/0008-5472.CAN-19-3922

Figure 1. Mutation status of ARID1A and its level of protein expression are associated with sensitivity to NVP-AUY922 in PDAC cell lines.

Figure 1.

A. Non-synonymous, exonic mutations of BAF complex members` genes, across a panel of 18 commercially available PDAC cell lines and 5PDX-derived cell lines. B. Box plot comparing IC50 for NVP-AUY922 among all cell lines in study, based on the mutation status of each recurrently mutated gene typically found in PDAC tumors (WT: wild type; MUT: mutant). Genes were included if N ≥ 3 models were found harboring a non-synonymous, exonic mutations for it. C. Bar chart showing IC50 for NVP-AUY922 values and ARID1A mutational status across all models analyzed in the study. D. Immunoblotting analysis of ARID1A protein in 23 PDAC cell lines. E. Sperman correlation of Moffit Basal Score vs log10(NVP-AUY922 IC50) in PDAC cell lines. Data represent mean ± SD. *, P <0.05; **, P <0.01; NS: not significant.