Table 1.
DDI involvement of drugs categorized by the therapeutic area
| ATC category | Therapeutic area | Number of drugs | Average degree |
|---|---|---|---|
| A | Alimentary tract and metabolism system | 219 | 254.47 |
| B | Blood and blood forming organs | 99 | 157.98 |
| C | Cardiovascular system | 177 | 356.35 |
| D | Dermatologicals | 117 | 202.60 |
| G | Genito-urinary system | 127 | 266.28 |
| H | Hormonal preparations | 42 | 258.90 |
| J | Antiinfectives for systemic use | 202 | 227.16 |
| L | Antineoplastic and immunomodulating agents | 268 | 274.51 |
| M | Musculo-skeletal system | 78 | 285.08 |
| N | Nervous system | 269 | 403.25 |
| P | Antiparasitic products, insecticides and repellents | 36 | 151.42 |
| R | Respiratory system | 111 | 267.98 |
| S | Sensory organs | 125 | 241.13 |
| V | Various | 95 | 121.93 |
| U | Unclassified | 243 | 143.42 |
*The statistic was based on the approved drugs recorded in the DDInter database only. The ATC code of each drug was extracted from DrugBank or DrugCentral, and the drugs that could not be mapped to the ATC codes were labelled ‘Unclassified’. ATC, WHO Anatomical Therapeutic Chemical Classification System.