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. 2021 Sep 22;50(D1):D848–D857. doi: 10.1093/nar/gkab814

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Breakdown of non-classically secreted proteins by sub-type. (A) PncsHub Statistics page from within the Investigation Module. (B) Overview of non-classically secreted proteins with a known or unknown pathway (left, middle). The known pathways are further divided into membrane vesicles (MVs) and other sub-types (left, upper), of which there are 27 proteins that can be secreted by both MV and one other pathway. The unknown pathway is further annotated with inferred pathways (left, lower). Finally, the other known sub-types are separated into the remaining six sub-types (right): ABC Transporter, flagella export apparatus (FEA), fimbrillin-protein exporter (FPE), Holin, SecA2 (the alternate Sec pathway), and type VII secretion system (T7SS) pathways, and in addition to the 27 overlapping proteins that are also secreted by MV, there is one protein that can be secreted by both T7SS and SecA2.