Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 22;50(D1):D848–D857. doi: 10.1093/nar/gkab814

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 4. — Graphical illustration of the functional modules in PncsHub. (A, B) Example sequences were submitted as query proteins to both the HMM and retrained PeNGaRoo prediction tools: EsxB (PNCS00367), LF (PNCS00598), SrpC (PNCS04914), and the negative control KdgA (UniProt ID: P50846). EsxB, LF, and SrpC are experimentally validated non-classically secreted substrates (not included into any of our training datasets), but only EsxB is included in the ‘filter list’. (C) LF and SrpC were subsequently transferred to our Relationship Analysis Module to determine likely secretion pathways using (D) Similarity Analysis, (E) Phylogenetic Analysis, and (F) Homology Network Analysis.