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. 2021 Sep 27;50(D1):D518–D525. doi: 10.1093/nar/gkab852

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — G protein couplings and selectivity. (A) G protein couplings encompass Guide to Pharmacology (GtP) primary/secondary transducers (22) and log(E_max/EC₅₀), pEC₅₀ and E_max values from profiling studies (3–5) and a means thereof. The confidence and coverage of quantitative couplings can be adjusted based on counts of supporting datasets (default 2) and standard deviations from basal signal (default 1.4). (B) G protein selectivity profiles can be intersected in a Venn diagram counting the receptors in each class. (C), G protein selectivity trees map couplings to trees classifying receptors by class, ligand type and receptor families sharing endogenous ligand(s). (B, C) Dashed arrows illustrate paths to obtain coupling-based selection of receptor sets for further study.