Table 2.
Improvements and the number of MTIs with different validation methods provided by miRTarBase
| Features | miRTarBase 8.0 | miRTarBase 9.0 |
|---|---|---|
| Release date | 15 September 2019 | 15 September 2021 |
| Known miRNA entry | miRBase v22 | miRBase v22 |
| Known gene entry | Entrez 2019 | Entrez 2021 |
| Species | 32 | 37 |
| Curated articles | 11 021 | 13 389 |
| miRNAs | 4312 | 4630 |
| Target genes | 23 426 | 27 172 |
| CLIP-seq datasets | 331 | 440 |
| Curated MTIs | 479 340 | 2 200 449 |
| Text mining technique to prescreen literature | Enhanced NLP+ scoring system | Enhanced NLP+ scoring system |
| Download by validated miRNA target sites | Yes | Yes |
| Browse by miRNA, gene and disease | Yes | Yes |
| Regulation of miRNAs | Yes | Yes |
| Cell-free miRNA expression | Yes | Yes |
| miRNAs in extracellular vesicles | No | Yes |
| Human miRNA tissue atlas | No | Yes |
| Editing events in miRNAs | No | Yes |
| SNPs and DRVs | No | Yes |
| MTIs supported by strong experimental evidence | ||
| Number of MTIs validated by ‘reporter assay’ | 13 922 | 16 257 |
| Number of MTIs validated by ‘western blot’ | 12 179 | 14 665 |
| Number of MTIs validated by ‘qPCR’ | 13 263 | 16 483 |
| Number of MTIs validated by ‘reporter assay and western blot’ | 10 257 | 12 171 |
| Number of MTIs validated by ‘reporter assay or western blot’ | 15 710 | 18 751 |