Comparison 1. Indomethacin vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mortality	2	73	Risk Ratio (M‐H, Fixed, 95% CI)	1.32 [0.45, 3.86]
2 Chronic lung disease in survivors	2	45	Risk Ratio (M‐H, Fixed, 95% CI)	0.91 [0.62, 1.35]
3 Intraventricular haemorrhage ‐ all grades	2	75	Risk Ratio (M‐H, Fixed, 95% CI)	1.21 [0.62, 2.37]
4 Necrotising enterocolitis	1	47	Risk Ratio (M‐H, Fixed, 95% CI)	0.41 [0.05, 3.68]
5 Retinopathy of prematurity ‐ all grades (infants examined)	2	55	Risk Ratio (M‐H, Fixed, 95% CI)	0.68 [0.26, 1.78]
6 Symptomatic PDA	3	97	Risk Ratio (M‐H, Fixed, 95% CI)	0.36 [0.19, 0.68]
7 PDA ligation	2	73	Risk Ratio (M‐H, Fixed, 95% CI)	0.45 [0.17, 1.21]
8 Length of ventilation ‐ days	3	97	Mean Difference (IV, Fixed, 95% CI)	‐5.00 [‐17.33, 3.34]
9 Length of hospital stay ‐ Days	1	26	Mean Difference (IV, Fixed, 95% CI)	‐11.0 [‐45.21, 23.21]
10 Duration of supplemental oxygen ‐ days	3	97	Mean Difference (IV, Fixed, 95% CI)	‐12.53 [‐23.80, ‐1.26]