Figure 3.

Regulation of molecules and pathways by NP-based drug combinations. Mechanisms of molecular regulation were explicitly described (including the induction of protein degradation, the up or down-regulation of molecule's cleavage, activity, phosphorylation, ubiquitination, and expression). The biological regulation of drug combinations was also provided (e.g. the induction of cell cycle arrest, inhibition of metabolite biosynthesis, etc.). These regulation data were linked to their in-vitro or in-vivo disease model, and an extended description on each regulated molecule could be accessed by clicking the ‘Molecule Info’ buttons.