Table 1.

A summary of the Pi database contents (the discovery mode; on 15 August, 2021).

		Genomic predictor				Annotation predictor				Benchmarking (AUC)
Code	Number of targetsa	nGene	cGene	eGene	Number of seed (core) genesb	dGene	pGene	fGene	Number of crosstalk genesc	Pi	Naïved	GAe	EXf	TMg	Name
AA	15 195	33	42	174	229	30	16	19	43	-	-	-	-	-	Alopecia areata
AAV	15 167	15	29	10	47	12	7	7	44	-	-	-	-	-	ANCA-associated vasculitis
ALG	15 194	62	112	49	168	34	10	20	36	0.882	0.714	0.574	-	0.853	Allergy
AS	15 409	410	682	85	1035	173	72	93	34	0.818	0.779	0.598	0.500	0.782	Ankylosing spondylitis
ASM	15 246	125	206	96	359	66	24	41	46	0.918	0.760	0.591	0.523	0.839	Asthma
ATD	15 292	134	186	243	458	82	31	47	40	-	-	-	-	-	Autoimmune thyroid disease
BD	15 174	21	55	20	83	27	7	17	47	-	-	-	-	-	Behcet’s disease
CEL	15 286	150	280	177	521	106	43	55	35	-	-	-	-	-	Celiac disease
CRO	15 512	548	994	276	1482	230	96	108	35	0.920	0.628	0.537	0.539	0.795	Crohn’s disease
GD	15 217	57	106	58	175	38	15	27	37	-	-	-	-	-	Graves’ disease
Gt	15 173	42	36	24	83	7	4	4	41	0.794	0.741	0.586	-	0.766	Gout
JIA	15 235	91	178	81	306	67	30	30	36	0.910	0.747	0.550	0.724	0.972	Juvenile idiopathic arthritis
MS	15 360	263	566	187	830	111	63	58	35	0.891	0.699	0.517	0.509	0.761	Multiple sclerosis
OA	15 165	19	33	3	45	2	2	3	36	0.718	0.666	0.506	0.570	0.806	Osteoarthritis
PBC	15 264	134	229	153	432	74	36	38	36	0.558	0.667	0.527	-	0.570	Primary biliary cholangitis
PSO	15 511	588	901	132	1379	220	91	118	33	0.916	0.651	0.584	0.531	0.773	Psoriasis
RA	15 432	214	392	571	1014	154	66	70	33	0.913	0.688	0.603	0.578	0.848	Rheumatoid arthritis
SAR	15 310	221	177	90	338	45	20	37	40	0.875	0.681	0.545	0.510	0.869	Sarcoidosis
SLE	15 397	318	592	174	902	140	50	68	40	0.939	0.629	0.611	0.521	0.916	Systemic lupus erythematosus
SSC	15 189	39	81	64	143	32	17	20	36	0.783	0.699	0.535	-	0.954	Systemic scleroderma
T1D	15 364	246	368	292	761	117	53	70	50	0.818	0.692	0.537	0.504	0.866	Type I Diabetes
UC	15 508	501	885	246	1365	208	92	106	33	0.914	0.741	0.567	0.619	0.801	Ulcerative colitis
IGE	15 164	23	38	18	63	20	7	15	36	-	-	-	-	-	IgE and allergic sensitization
IIM	15 220	80	78	37	144	34	8	23	33	-	-	-	-	-	Idiopathic inflammatory myopathies
KD	15 169	27	44	26	79	21	6	8	34	-	-	-	-	-	Kawasaki disease
MG	15 179	16	34	21	63	23	3	15	35	-	-	-	-	-	Myasthenia gravis
NAR	15 173	29	27	9	60	13	8	10	36	-	-	-	-	-	Narcolepsy
PSC	15 422	433	705	340	1122	196	78	111	33	-	-	-	-	-	Primary sclerosing cholangitis
SJO	15 199	44	64	38	119	28	10	14	33	-	-	-	-	-	Sjogren’s syndrome
VIT	15 361	171	227	470	772	99	52	54	34	-	-	-	-	-	Vitiligo

^aThe total number of target genes prioritized.

^bThe total number of genomic seed genes.

^cThe total number of pathway crosstalk genes.

^dAn approach prioritizing a gene by how often it has been targeted by existing approved drugs.

^ePrioritization based on individual evidence from Genetic Associations (Open Targets).

^fPrioritization based on individual evidence from gene EXpression (Open Targets).

^gPrioritization based on individual evidence from Text Mining (Open Targets).