Table 1.
Growth figures describing the increase in content of human interactions with respect to the last database publication in 2013 (5)
| Human | |||
|---|---|---|---|
| Interaction type | 2013: version 25 (# interactions) | 2022: version 35 (# interactions) | Content growth (# interactions) |
| Protein–protein | 155 855 | 616 304 | 460 449 |
| Signaling or metabolic | 20 682 | 25 046 | 4364 |
| Gene regulatory | 5658 | 18 912 | 13 254 |
| Genetic | 265 | 7936 | 7671 |
| Drug–target | 33 081 | 191 650 | 158 569 |
| Gene target sets | 2013: version 25 (# sets) | 2022: version 35 (# sets) | Content growth (# sets) |
| Pathways | 4601 | 5578 | 977 |
| Protein complex-derived sets | 39 685 | 244 987 | 205 302 |
| miRNA–gene target | 0 | 5474 | 5474 |
| Transcription factor–gene target | 0 | 800 | 800 |
| Enhancer–gene target setsa | 0 | 217 790 | 217 790 |
a
It should be noted that enhancer–gene target sets are highly redundant across different cell types.