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. 2021 Oct 11;50(D1):D888–D897. doi: 10.1093/nar/gkab921

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Schematic representation of VarEPS for data processing and online analysis service. SARS-CoV-2 genome sequences were integrated to perform metadata curation and quality control procedures. Sequence data were mapped to the reference genome for variation annotation. Each annotated variant was used to calculate effects on translation efficiency, secondary structure, binding capacity of ACE2 and neutralizing antibodies and efficacy of primers. Our web portal provides multiple query selections to display results on both known and virtual mutations. The system also provides online analysis service for custom submitted sequences.