Table 5.
Distribution of kinase states by kinase family among 496 AlphaFold2 structure predictions.
| Spatial label | Dihedral label | Annotation | AGC | CAMK | CK1 | CMGC | NEK | RGC | STE | TKL | TYR | Other | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DFGin | BLAminus | Active | 55 | 89 | 14 | 53 | 6 | - | 34 | 37 | 50 | 13 | 351 |
| BLBplus | SRC-inactive | - | 7 | - | 5 | - | 5 | 13 | 11 | 20 | 1 | 62 | |
| ABAminus | Active-like | - | 9 | - | - | - | - | - | 1 | 3 | 3 | 16 | |
| BLBminus | 2 | 4 | - | 3 | 7 | - | 9 | 1 | 2 | 1 | 29 | ||
| BLAplus | FGFR-inactive | 2 | - | - | - | - | - | - | 1 | 2 | 1 | 6 | |
| BLBtrans | CDK-inactive | - | - | - | - | - | - | 1 | - | - | 1 | 2 | |
| None | - | - | - | - | - | - | - | - | 6 | 2 | 8 | ||
| DFGinter | BABtrans | - | - | - | - | - | - | - | - | - | - | - | |
| None | AURKA-inactive | - | - | - | - | - | - | - | 1 | 7 | - | 8 | |
| DFGout | BBAminus | Type-2 binding | - | - | - | - | - | - | - | - | 6 | - | 6 |
| None | DFGout-like | 2 | - | - | - | - | - | 1 | 1 | 1 | - | 5 | |
| None | None | - | 1 | - | - | - | - | 1 | - | - | 1 | 3 | |
| Total | - | 61 | 110 | 14 | 61 | 13 | 5 | 59 | 53 | 97 | 23 | 496 |
The table compares the state of kinase structures predicted by AlphaFold (available from http://alphafold.ebi.ac.uk) across different kinase families.