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. 2021 Sep 11;50(D1):D610–D621. doi: 10.1093/nar/gkab778

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Integrative analysis of colon cancer network using GRAND combined tools. (A) A differential network between the colon cancer network and the normal transverse colon network allows the selection of the top differential targeted genes and the top differential targeting TFs (B). (C) CLUEreg analysis suggested two compounds MK-5108 and CB7950998 to reverse the colon cancer network targeting score. (D) The TF targeting scores of MK-5108, an investigational kinase inhibitor, is similar to the scores of two other known kinase inhibitors. (E) Both kinases have different physiological roles which could set the basis for a combination therapy. (F) TF enrichment analysis of MK-5108 TF targeting scores suggested a possible specificity for colon tissue. * P-value < 10^–5.