Figure 1.

Overview of the TissueNexus database. (A) Hand-curation of tissue labels for human RNA-seq samples of the DEE2 database. The gene expression data in the GTEx portal are also included. A total of 1,341 RNA-seq datasets containing 52,087 samples were obtained for 49 tissues or cell lines. (B) Construction of functional gene networks for each tissue or cell line. The networks are stored in the MySql database. (C) Network search, visualization and analysis. After querying a gene, its local network containing top-connected neighbors is obtained and visualized. The web server also provides a series of analyses for the network and the queried gene, including analyses of Gene Ontology enrichment, disease enrichment, evidence supporting the functional relationship of gene pairs, expression level across tissues, annotation of associated diseases/traits, and annotation of associated drugs.