Figure 4.

Comparison of TissueNexus to existing tissue gene networks based on their performance in predicting risk genes for different types of diseases. (A) AUROC. (B) AUPRC. (Notes: The BaiHui database contains only a brain gene network and is therefore compared on only brain disorders; For the GRAND database, Because it contains multiple sample-specific networks for each tissue, we calculate the mean and standard deviation of AUROC and AUPRC. The mean of AUROC and AUPRC is presented, with the standard deviation provided in Supplementary Table S2; GRAND does not contain networks for prostate so that prostate cancer gene prediction is not performed on GRAND). Disease abbreviations: AD (Alzheimer’s disease), PD (Parkinson’s disease), ASD (autism spectrum disorder), SZ (schizophrenia), MDD (major depression disorder), BC (breast cancer), PC (prostate cancer), LC (lung cancer), CC: (colon cancer), MSC (melanoma skin cancer), AF (atrial fibrillation), T2D (type 2 diabetes), OB (obesity).