Figure 5.

The antibody isotype IgG1 was the dominant responder to reovirus infection. (A) Levels of antibody isotypes IgG1, IgG2, IgG3 and IgG4, IgM, IgA and IgE for five patients receiving 1×10¹⁰ TCID₅₀ doses of reovirus alone for 5 days at the start of each cycle. Error bars=SEM. (B) Antibody class profiles (top) and specific IgG isotype bias (bottom) between baseline and cycle 1 day 8 (C1D8). *P<0.05. (C) Antibody isotype levels throughout treatment of a representative patient, showing IgG1 as the main constituent increased at C1D8. (D) Neutralizing antireovirus antibody levels for the same patient.