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. 2021 Dec 18;25(1):103643. doi: 10.1016/j.isci.2021.103643

Figure 4.

Figure 4

Mutation of the LL motif suppresses the dendritic and post-synaptic delivery of β2-AR and M3R in hippocampal neurons

(A) Sequences of the CT of α2B-AR, β2-AR, and M3R.

(B) The dendritic expression of β2-AR and its LL-AA mutant. Scale bar, 50 μm.

(C) The dendritic expression of M3R and its LL-AA mutant. Scale bar, 50 μm.

(D) Quantitative data shown in (B) and (C). The data are expressed as percentages of WT. Bars represent mean ± SE (n = 6–10 neurons in at least 3 experiments). Unpaired Student's t test; ∗p < 0.05 versus respective WT.

(E) The post-synaptic expression of β2-AR and its LL-AA mutant. Scale bar, 5 μm.

(F) The post-synaptic expression of M3R and its LL-AA mutant. Scale bar, 5 μm.

(G) Quantitative data shown in (E) and (F). The data are expressed as percentages of WT. Bars represent mean ± SE (n = 30–50 spines in at least 3 experiments). Unpaired Student's t test; ∗p < 0.001 versus WT.