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Top 30 factors associated with PHQ-9 score adjusted by age, sex, and age by sex interaction. LASSO regression model one comprised age, sex, and age by sex interaction. The LASSO-predicted value was used to estimate a covariate-adjusted effect for all other candidate variables. BMI, body mass index; LASSO, least absolute shrinkage and selection operator; PHQ-9, Patient Health Questionnaire-9; WBC, white blood cell.
