Figure 3.

Double-dose effect of anti-EFG1 2′OMe oligomer on G. mellonella infected with C. albicans

(A) Survival curves of infected larvae treated with a double dose of anti-EFG1 2′OMe oligomer (0 and 12 h post infection). Larvae infected with C. albicans cells were treated with 40 and 100 nM of anti-EFG1 2′OMe oligomer. As controls, larvae infected were injected only with PBS. (B) The health index scores of larvae treated with a double dose of 100 nM of anti-EFG1 2′OMe oligomer. Control represents the infected larvae treated only with PBS after 12 h post infection. ∗Significant difference among control and a double dose of 40 nM of anti-EFG1 2′OMe oligomer for all times (p < 0.05). ∗∗∗Significant difference among control and a double dose of 100 nM of anti-EFG1 2′OMe ASO for all times (p < 0.001).