Figure 2.

Schematic representation of mechanisms of selected circRNAs

(A) Knock down of circSlc8a1 alleviated cardiac hypertrophy through sponging miR-133a, whereas circSlc8a1 overexpression promoted cardiac hypertrophy. (B) When delivered to hypertrophic myocardium using AAV9 vectors, artificial circRNA (also termed circmiR), which targets miR-132 and miR-212, could reduce cardiac hypertrophy and improve heart function. (C) circHIPK3 silencing by RNA interference inhibited cardiomyocyte hypertrophy by reducing CaSR expression and consequently preserved cardiac function.