Table 1.

circRNAs involved in the regulation of cardiac hypertrophy

circRNAs	Mechanisms	Effect on cardiac hypertrophy	References
HRCR	acting as an endogenous miR-223 sponge to repress its activity and aggravate the influence of ARC	negative	Wang et al.50
circSlc8a1	serving as a sponge for miR-133a and further affecting its targets: Srf, Ctgf, Adrb1, and Adcy6	positive	Lim et al.51
circRNA-000203	sponging miR-26b-5p and miR-140-3p to abolish the suppression of target gene Gata4 and then upregulate GATA4 expression	positive	Li et al.52
circmiR	synthesizing a circRNA with certain miRNA binding sites artificially to target miR-132 and miR-212	negative	Lavenniah et al.53
circRNA wwp1	exerting functions by targeting miR-23a and ANF on isoproterenol-induced cardiac hypertrophy	negative	Yang et al.54
circHIPK3	sponging miR-185-3p and subsequently modulating its target, CaSR	positive	Xu et al.55
circYap	binding directly with TMP4 and ACTG and facilitating the interaction between the two to suppress actin polymerization and the following fibrosis	negative	Wu et al.56

circmiR, custom circRNA sponge; ANF, atrial natriuretic factor; CaSR, calcium-sensing receptor; TMP4, tropomyosin-4; ACTG, gamma-actin.