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. Author manuscript; available in PMC: 2022 Jan 5.
Published in final edited form as: Cell Rep. 2021 Nov 30;37(9):109933. doi: 10.1016/j.celrep.2021.109933

Figure 6. L-DOPA and carbidopa treatment effective at reducing mechanical hypersensitivity in SNI mice.

Figure 6.

(A) Mechanical withdrawal thresholds on ipsilateral paw (left) and contralateral paw (right) between treatment conditions. Groups: SNI, sham, SNI + L-DOPA, sham + L-DOPA, and SNI + delayed L-DOPA (supplementation starting 2 weeks post-SNI surgery rather than on the day of SNI surgery; n = 6–11).

(B) Mean scores of responses to cold in the acetone test on ipsi- and contralateral paws in several treatment conditions (n = 7–11).

(C) Input-output plots documenting L-DOPA-and-carbidopa-induced decrease in both pyramidal excitability (left) and input resistance (right; n = 13–27).

(D) Rescue of HCN channel activity in L-DOPA-and-carbidopa-treated SNI mice (left), with open channel probabilities on level with sham mice at resting membrane potential (right; n = 27–34).

Values represented as means ± SEM: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.