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Mechanisms of DNA adduct formation by PAHs. BP is metabolized by CYP1A1 and CYP1B1 enzymes to form 7,8-epoxide metabolite. This product is then metabolized by epoxide hydrolase to produce 7,8-diol. After this step, CYP1A1/1B1 metabolizes 7, 8-diol to form the ultimate carcinogenic metabolite, 7, 8-diol-9, 10-epoxide. This metabolite reacts with N2 of guanosine to form DNA adducts, which contribute to carcinogenesis.
