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PAH exposure in Cyp1a1-null mice causes upregulation of hepatic CYP1A2 enzyme and attenuation of hepatic DNA adduct formation. In the lungs, NQO1 enzyme is upregulated. Upon analysis, Cyp1a1-null mice demonstrated reduced lung tumor formation compared to WT mice. In Cyp1a2-null mice, PAH exposure caused an upregulation of CYP1A1 enzyme in both the liver and the lungs, which increases DNA adduct formation. These mice showed increased lung tumor formation compared to WT mice.
