Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Role of CYP1A2 in the sustained CYP1A1 induction. We propose that CYP1A2 may do this by metabolizing MC to MC-X, which binds to the AHR complex. After dissociation, the MC-X-AHR complex binds to ARNT at the XRE binding site and forms a MC-X DNA adduct. We posit that the MC-X binds covalently to DNA, and prevents binding of DNMT and HDAC that keep the promoter in silenced state, leading to sustained CYP1A1 induction.
