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. Author manuscript; available in PMC: 2022 Jan 5.
Published in final edited form as: Exp Hematol. 2018 Aug 17;67:60–64.e2. doi: 10.1016/j.exphem.2018.08.003

Figure 2.

Figure 2.

(A) Effect of oral administration of ORY-3001 on HbF, F retics, and γ-globin mRNA in two anemic baboons, PA8695 and PA8698. The drug was administered for three consecutive days on days 1–3 at a dose of 100 μg/kg/d. Total hemoglobin levels were: PA8698: 6.1 g/dL predose, 6.3 g/dL postdose; PA8695: 7.0 g/dL predose, 6.7 g/dL postdose. (B) HPLC analysis of globin chain synthesis in 8695 and 8698 predose and 8 days after administration of the first dose of drug. Absolute HbF levels were: PA 8698: 0.9 g/dL predose; 4.8 g/dL postdose; PA8695 1.1 g/dL predose, 3.8 g/dL postdose. Levels of α-globin chain synthesis were: PA8698: 1.01 α/γ+β predose, 1.23 α/γ+β postdose; PA8695: 1.09 α/γ+β predose, 1.09 α/γ+β postdose.