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Effect of OG-S1335 on F retics, F cells, and γ-globin mRNA in SCD mice
| Treatment | Dose (mg/kg/d) | F retics (%) | F cells (%) | γ-globin mRNA (γ/γ+β) |
|---|---|---|---|---|
| Vehicle | 0 | 3.57 ± 0.57 | 3.53 ± 0.55 | 0.003 ± 0.000 |
| ORY-3001 | 0.25 | 8.77 ± 1.20 | 6.40 ± 1.45 | 0.010 ± 0.001 |
| ORY-3001 | 0.5 | 10.17 ± 2.23 | 7.78 ± 1.85 | 0.0173 ± 0.005 |
| ORY-3001 | 1.0 | 11.23 ± 2.91 | 9.30 ± 0.46 | 0.029 ± 0.007 |
