Fig. 4.

Open questions and opportunities relating gut microbiome and cellular senescence. (1) How the gut metabolome changes with age, and how it could be related to cellular senescence and SASP is not known. (2) Whether the known effects of senolytics and anti-senescence agents are mediated through gut microbiome modulation is not clear. (3) How does SASP of accumulating senescent cells in the intestine can affect the diversity and composition of gut microbiome remains to be completely elucidated. Illustration created at app.biorender.com