Relative point in time	Case course
Day −30	66-year-old male admitted with chest pain, diagnosis of subsegmental pulmonary embolism. Edoxaban is started after 5 days of enoxaparin. Coronavirus disease 2019 polymerase chain reaction is compatible with previous infection.
Day −23	At home discontinuation of edoxaban.
Day 1	Admitted with subacute balance disorders. Magnetic resonance imaging confirms multi-territory stroke. Re-initiation of edoxaban.
Day 3	A transthoracic echocardiogram shows no significant abnormalities.
Day 14	Ambulatory transoesophageal echocardiogram shows a small vegetation on the aortic valve with moderate aortic regurgitation.
Day 16	Blood cultures remain negative. Prostate specific antigen is significantly elevated (317 ng/mL).
Day 17	Prostate biopsies are taken. Histology confirms prostate carcinoma.
Day 19	Positron emission tomography shows multiple fluoro-deoxy-glucose avid osteoblastic bone lesions.
Day 31	Androgen deprivation therapy is initiated.
Day 120	Our patient is in good general condition. His gait has improved. Prostate specific antigen is 0.84 ng/mL.
Day 150	A control transthoracic echocardiogram shows no visible vegetations.