Table 1.
Expression of individual γ-globin chains
| Sample | γ/γ + β | α/γ + β | Iγ/Vγ | |
|---|---|---|---|---|
| Fetal cord blood | 58d #1 | 72.6 | 1.09 | 1.85 |
| 58d #2 | 90.1 | 1.04 | 1.85 | |
| Mean | 81.4 | 1.07 | 1.85 | |
| Baboon (bled) | 7254 | 4.1 | 1.09 | 0.64 |
| 7255 | 9.6 | 1.05 | 0.56 | |
| 7258 | 7.4 | 0.99 | 0.76 | |
| Mean 6 SD | 7.03 ± 2.77 | 1.04 ± 0.05 | 0.65 ± 0.10 | |
| Baboon (decitabine) | 7001 | 55.2 | 0.98 | 0.40 |
| 7002 | 55.3 | 1.24 | 1.12 | |
| 7254 | 50.5 | 1.05 | 0.90 | |
| 7255 | 41.9 | 1.05 | 0.45 | |
| 7257 | 55.1 | 1.06 | 0.95 | |
| Mean ± SD | 51.6 ± 5.79 | 1.08 ± 0.09 | 0.75 ± 0.32 | |
| CD34+ BM cultures | 6973 | 60.5 | 1.16 | 1.55 |
| 7002 | 54.2 | 1.08 | 2.10 | |
| 7255 | 33.3 | 1.04 | 1.52 | |
| 7256 | 49.5 | 1.07 | 1.71 | |
| 7257 | 42.9 | 1.01 | 1.79 | |
| 7258 | 45.2 | 1.05 | 1.46 | |
| Mean ± SD | 47.6 ± 9.44 | 1.07 ± 0.07 | 1.69 ± 0.23 |
Expression of individual γ-globin chains in hemolysates from cord blood, peripheral blood of bled and decitabine-treated baboons, and adult baboon CD34+ bone marrow erythroid progenitor cell cultures.
BM = bone marrow; SD = standard deviation.