TABLE 3.
Blood pressure and pulse rate differences from visit 1 to visit 2 and visit 1 to visit 3
| Between visits 1 and 2 | Between visits 1 and 3 | |||||||
| Measurement | n | Difference [mean (SD)] | CV [mean (SD)] | Sample size | N | Difference, mean (SD) | CV, mean (SD) | Sample size |
| SBP (mmHg) | ||||||||
| Attended office | 287 | 1.24 (15.71) | 6.22 (5.03) | 106 | 287 | 0.91 (15.27) | 6.25 (4.79) | 102 |
| Unattended office | 287 | 1.49 (12.49) | 5.41 (4.45)† | 68 | 287 | 1.06 (14.47) | 6.16 (5.21) | 92 |
| Combined home | 287 | 0.81 (6.01) | 2.59 (2.21)§ | 18 | 287 | −0.05 (7.68) | 3.31 (2.73)§ | 28 |
| Morning home | 287 | 0.97 (6.77) | 2.82 (2.54)∗ | 22 | 287 | 0.11 (8.91) | 3.77 (3.12)§ | 36 |
| Evening home | 279 | 0.63 (7.41) | 3.16 (2.82) | 26 | 276 | −0.29 (8.57) | 3.77 (3.10) | 34 |
| DBP (mmHg) | ||||||||
| Attended office | 287 | 0.51 (7.91) | 5.70 (4.88) | 108 | 287 | −0.39 (8.78) | 6.43 (5.40) | 132 |
| Unattended office | 287 | 0.46 (6.77) | 5.47 (4.68) | 80 | 287 | 0.70 (8.39) | 6.62 (5.71) | 122 |
| Combined home | 287 | 0.51 (3.78) | 2.95 (2.40)§ | 28 | 287 | 0.32 (5.58) | 4.17 (3.45)§ | 56 |
| Morning home | 287 | 0.65 (4.13) | 3.16 (2.63) | 32 | 287 | 0.68 (6.23) | 4.46 (3.88)∗ | 68 |
| Evening home | 279 | 0.33 (4.66) | 3.62 (3.09)∗ | 40 | 276 | −0.18 (5.96) | 4.76 (3.67) | 62 |
| Pulse rate (beats per minute) | ||||||||
| Attended office | 287 | 0.94 (8.48) | 5.68 (5.31) | 124 | 287 | 0.55 (9.79) | 6.81 (5.37) | 164 |
| Unattended office | 287 | 0.60 (7.44) | 5.24 (4.79) | 96 | 287 | 0.67 (8.37) | 6.29 (5.11)∗ | 120 |
| Combined home | 287 | 0.31 (3.71) | 2.79 (2.58)§ | 26 | 287 | −0.05 (4.98) | 3.84 (3.14)§ | 44 |
| Morning home | 287 | 0.26 (4.25) | 3.19 (3.07)‡ | 34 | 287 | −0.12 (5.69) | 4.40 (3.75)‡ | 58 |
| Evening home | 279 | 0.32 (4.25) | 3.17 (2.82) | 34 | 276 | −0.09 (5.64) | 4.39 (3.47) | 56 |
Values are means (SD) of the variables. CV denotes inter-individual coefficient of variation (units are dimensionless), and significances of differences from the superjacent row (those with full evening measurement information were compared in the comparison between morning and evening blood pressures) are marked: ∗P less than 0.05; †P less than 0.01; ‡P less than 0.001; and §P less than 0.0001. Sample size is the number of total participants required for a parallel-group design clinical trial in order to detect a difference between the two drug effects of 10/5 mmHg in SBP/DBP, or 5 beats per minute pulse rate, with a power of 0.90 and significance level of 0.05 in each measurement.