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. 2021 Nov 19;9(1):2103836. doi: 10.1002/advs.202103836

Figure 3.

Figure 3

a) A scheme indicating the step‐by‐step synthesis of H‐MnO2–PEG nanoparticles and the subsequent dual‐drug loading. b) TEM images of H‐MnO2–PEG after incubation in buffers with different pHs (7.4 and 5.5) for various periods of time. Reproduced with permission.[ 32 ] Copyright 2017, Springer Nature. c) Schematic illustration of pH‐responsive STING‐NVs that efficiently load CDG at physiological pH, stabilized CDG, delivered CDG to immune cells, conditionally released CDG in the acidic endosome, and facilitated endosome escape of CDG for cancer immunotherapy. d) pH‐responsive cumulative CDG release from STING‐NVs. e) The signal ratio of FluoCDG outside/inside (O/I) endolysosome. Reproduced with permission.[ 33 ] Copyright 2020, Wiley‐VCH. f) The design of pH low insertion peptide (pHLIP)‐modified Fc molecules or antibodies and the proposed immunotherapeutic mechanism. g) Quantification of the increase in NK cell activation (CRTAM‐positive) CRTAM: class‐I restricted T cell‐associated molecule. h) the percentage of proliferating cell nuclear antigen (PCNA)‐positive cells in metastasis tumors treated by various formulations. Reproduced with permission.[ 34 ] Copyright 2018, Wiley‐VCH. p‐Values: *p < 0.05; **p < 0.01; ***p < 0.001.