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. 2021 Nov 19;9(1):2103836. doi: 10.1002/advs.202103836

Figure 8.

Figure 8

a) Schematic on the preparation process of PNB–IR780/siP and illustration of the pH/ATP cascade‐responsive nanocourier targeting tumor delivery and mediated photothermal tumor immunotherapy in vivo. b) ATP‐triggered uploading of siP from different micelles for 10 min. c) PD‐L1 mRNA expression on 4T1 cells treated with various preparations (n = 3, mean ± SD). a: PBS, b: PB–IR780/siP at pH 7.4, c: PB–IR780/siP at pH 6.8, d: PNE–IR780/siP at pH 7.4, e: PNE–IR780/siP at pH 6.8, f: PNB–IR780/siP at pH 7.4, g: PNB–IR780/siP at pH 6.8, h: Lipo–siP at pH 7.4, i: Lipo–siP at pH 6.8. d) Quantitative presentation of PD‐L1 protein. e) Representative bioluminescence images and H&E assays of lungs. f) The frequency of tumor‐infiltrating CD4+ T cells, CD8+ T cells, and Tregs in mice with various treatments (n = 3, mean ± SD). g) CD8+ T cells: Treg ratios and CD4+ T cells: Treg ratios in the distal tumors (n = 3, mean ± SD). SD: standard deviation. Reproduced with permission.[ 82 ] Copyright 2021, Elsevier Ltd. p‐Values: *p < 0.05; **p < 0.01; ***p < 0.005.