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. 2021 Nov 19;9(1):2103836. doi: 10.1002/advs.202103836

Figure 9.

Figure 9

a) Schematic illustration of the BCPN for improved immunotherapy by cooperatively modulating the immune tumor microenvironment. b) Representative CLSM images of fluorescence distribution in 4T1 multicellular spheroid (MCSs) after 12 h incubation with acid‐sensitive binary cooperative prodrug nanoparticle (ASPN@NR) pretreated in acid buffers. c) The tumor growth curves in 4T1‐tumor‐bearing mice following the indicated treatments. d) The number of lung metastatic nodules of mice bearing 4T1 tumors at the end of the antitumor study. Reproduced with permission.[ 83 ] Copyright 2018, Wiley‐VCH. e) The proposed antitumor mechanism of the NLG919@DEAP‐DPPA‐1 nanoparticle. f,g) The percentages of CD8+ T cells (f) and IFN‐γ‐producing cytotoxic T cells (g) in tumors from various treatment groups (n = 3) were analyzed using flow cytometry on day 12 after the commencement of treatment. h,i) The expression of IFN‐γ (h) and IL‐2 (i) in tumors from various treatment groups (n = 3). Reproduced with permission.[ 85 ] Copyright 2018, American Chemical Society. p‐Values: *p < 0.05; **p < 0.01; ***p < 0.005.