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. 2006 Oct 18;2006(4):CD003770. doi: 10.1002/14651858.CD003770.pub3

Lygidakis 1995.

Methods RCT
Participants Colorectal cancer (CRC) metastatic to the liver eligible for resection
Interventions LR (liver resection) + hepatic artery chemotherapy (HAI)
Outcomes Overall survival (OS), 
 Disease free survival (DFS), 
 Hepatic resection FS, 
 toxicity,
Notes marked benefit in Hepatic resection with multi‐modality HAI