Table 3.
Association between E-DII and sex hormones stratified by type of menopause.
| Type of menopause | TT | FT | E2 | FE2 | SHBG | TT/E2 |
|---|---|---|---|---|---|---|
| β (95%CI) | β (95%CI) | β (95%CI) | β (95%CI) | β (95%CI) | β (95%CI) | |
| Hysterectomy (n=288) | ||||||
| Continues | -0.001 | 0.004 | 0.02 | 0.02 | -0.01 | -0.02 |
| (-0.06, 0.06) | (-0.04, 0.05) | (-0.06, 0.1) | (-0.05, 0.1) | (-0.05, 0.03) | (-0.09, 0.05) | |
| Tertile 1 | Reference | Reference | Reference | Reference | Reference | Reference |
| Tertile 2 | -0.024 | -0.06 | 0.1 | 0.08 | 0.04 | -0.13 |
| (-0.34, 0.29) | (-0.33, 0.22) | (-0.25, 0.45) | (-0.27, 0.43) | (-0.12, 0.21) | (-0.61, 0.36) | |
| Tertile 3 | -0.037 | -0.03 | 0 | 0 | -0.01 | -0.04 |
| (-0.40, 0.33) | (-0.33, 0.27) | (-0.34, 0.34) | (-0.33, 0.33) | (-0.17, 0.14) | (-0.39, 0.31) | |
| P for trend | 0.98 | 0.88 | 0.83 | 0.88 | 0.76 | 0.86 |
| Natural menopause (n=895) | ||||||
| Continues | 0.05 | 0.03 | -0.05 | -0.06 | 0.02 | 0.10 |
| (0.01, 0.08) | (0.002, 0.06) | (-0.1, 0.01) | (-0.1, 0.026) | (-0.009, 0.04) | (0.06, 0.14) | |
| Tertile 1 | Reference | Reference | Reference | Reference | Reference | Reference |
| Tertile 2 | 0.08 | 0.03 | -0.26 | -0.28 | 0.07 | 0.33 |
| (-0.06, 0.22) | (-0.14, 0.2) | (-0.4, 0.11) | (-0.45, -0.12) | (-0.05, 0.19) | (0.18, 0.49) | |
| Tertile 3 | 0.25 | 0.17 | -0.16 | -0.21 | 0.11 | 0.41 |
| (0.07, 0.43) | (-0.02, 0.36) | (0.34, 0.01) | (-0.39, -0.04) | (0, 0.22) | (0.23, 0.6) | |
| P for trend | 0.02 | 0.86 | 0.01 | 0.01 | 0.20 | 0.001 |
E-DII, energy-adjusted dietary inflammation index; TT, total testosterone; FT, free testosterone; E2, estradiol; FE2, free estradiol; SHBG, sex hormone-binding globulin; TT/E2, the ratio of TT to E2.
E-DII tertile ranges: tertile 1, -5.04 to -0.69; tertile 2, -0.69 to 1.02; tertile 3, 1.02 to 4.55.
All model were adjusted for age, race, education, marital status, smoking, body mass index, waist circumference, time since menopause, parity, time of blood sampling and energy intake. The numbers in bold letters indicate that the result was considered significant difference.