Table 4.
Association between E-DII and sex hormones stratified by BMI.
| BMI | TT | FT | E2 | FE2 | SHBG | TT/E2 |
|---|---|---|---|---|---|---|
| β (95%CI) | β (95%CI) | β (95%CI) | β (95%CI) | β (95%CI) | β (95%CI) | |
| <25kg/m2 (n=276) | ||||||
| Continues | 0.01 | -0.008 | -0.006 | -0.02 | 0.03 | 0.02 |
| (-0.04, 0.06) | (-0.05, 0.035) | (-0.11, 0.1) | (-0.12, 0.08) | (-0.02, 0.07) | (-0.06, 0.10) | |
| Tertile 1 | Reference | Reference | Reference | Reference | Reference | Reference |
| Tertile 2 | 0.01 | -0.13 | -0.06 | -0.15 | 0.18 | 0.08 |
| (-0.18, 0.20) | (-0.36, 0.11) | (-0.3, 0.17) | (-0.4, 0.1) | (0.03, 0.33) | (-0.13, 0.28) | |
| Tertile 3 | 0.029 | -0.11 | 0.02 | -0.07 | 0.18 | 0.01 |
| (-0.18, 0.24) | (-0.36, 0.14) | (-0.24, 0.28) | (-0.35, 0.22) | (-0.01, 0.38) | (-0.20, 0.22) | |
| P for trend | 0.96 | 0.57 | 0.75 | 0.50 | 0.09 | 0.75 |
| 25~29.9kg/m2 (n=347) | ||||||
| Continues | 0.02 | 0.006 | -0.05 | -0.06 | 0.02 | 0.07 |
| (-0.01, 0.05) | (-0.03, 0.04) | (-0.12, 0.03) | (-0.14, 0.03) | (-0.03, 0.07) | (-0.01, 0.15) | |
| Tertile 1 | Reference | Reference | Reference | Reference | Reference | Reference |
| Tertile 2 | -0.12 | -0.16 | -0.22 | -0.25 | 0.06 | 0.11 |
| (-0.32, 0.08) | (-0.41, 0.09) | (-0.58, 0.13) | (-0.61, 0.11) | (-0.15, 0.26) | (-0.21, 0.42) | |
| Tertile 3 | 0.13 | 0.06 | 0.15 | 0.02 | 0.09 | 0.28 |
| (-0.06, 0.32) | (-0.13, 0.25) | (-0.53, 0.22) | (-0.6, 0.2) | (-0.12, 0.3) | (-0.08, 0.64) | |
| P for trend | 0.04 | 0.19 | 0.45 | 0.41 | 0.69 | 0.19 |
| ≥30kg/m2(n=560) | ||||||
| Continues | 0.04 | 0.04 | -0.03 | -0.03 | 0.007 | 0.07 |
| (0.002, 0.08) | (-0.004, 0.08) | (-0.09, 0.03) | (-0.1, 0.03) | (-0.03, 0.04) | (0.008, 0.14) | |
| Tertile 1 | Reference | Reference | Reference | Reference | Reference | Reference |
| Tertile 2 | 0.20 | 0.18 | -0.17 | -0.18 | 0.05 | 0.37 |
| (0.01, 0.38) | (0.02, 0.33) | (-0.4, 0.06) | (-0.42, 0.07) | (-0.09, 0.19) | (0.08, 0.66) | |
| Tertile 3 | 0.22 | 0.17 | -0.12 | -0.15 | 0.07 | 0.34 |
| (-0.01, 0.44) | (-0.04, 0.39) | (-0.33, 0.08) | (-0.37, 0.08) | (-0.1, 0.24) | (0.04, 0.64) | |
| P for trend | 0.14 | 0.12 | 0.32 | 0.33 | 0.7 | 0.07 |
E-DII, energy-adjusted dietary inflammation index; TT, total testosterone; FT, free testosterone; E2, estradiol; FE2, free estradiol; SHBG, sex hormone-binding globulin; TT/E2, the ratio of TT to E2.
E-DII tertile ranges: tertile 1, -5.04 to -0.69; tertile 2, -0.69 to 1.02; tertile 3, 1.02 to 4.55.
All models were adjusted for age, race, education, marital status, smoking, waist circumference, type of menopause, time since menopause, parity, time of blood sampling and energy intake. The numbers in bold letters indicate that the result was considered significant difference.