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(A) Alignment of Drosophila brainiac (upper sequence) and mouse Brainiac 1 (lower sequence). Identical amino acids are boxed. Regions showing a high degree of homology between mouse Brainiac 1 and members of the β3-GalT gene family are marked by a line above the sequence. (B) Alignment of domains conserved in murine β3-GalT genes and Drosophila brainiac. The regions showing high sequence similarity include an (E/D)DVXXG motif that has also been found in bacterial galactosyltransferases.
